Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias

被引：104

作者：

Carta, Manolo ^{[1
,2
]}

Carlsson, Thomas ^{[1
,2
]}

Munoz, Ana ^{[1
]}

Kirik, Deniz ^{[2
]}

Bjorklund, Anders ^{[1
]}

机构：

[1] Lund Univ, Dept Expt Med Sci, Wallenberg Neurosci Ctr, Neurobiol Unit, Lund, Sweden

[2] Lund Univ, Dept Expt Med Sci, Sect Neurosci, Brain Repair & Imaging Neural Syst Unit, Lund, Sweden

来源：

SEROTONIN-DOPAMINE INTERACTION: EXPERIMENTAL EVIDENCE AND THERAPEUTIC RELEVANCE | 2008年 / 172卷

关键词：

L-DOPA; dopamine; serotonin; dyskinesia; 5-HT agonists; serotonin autoreceptors;

D O I：

10.1016/S0079-6123(08)00922-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.

引用

页码：465 / 478

页数：14

共 87 条

[51] Receptor subtype-specific modulation by dopamine of glutamatergic responses in striatal medium spiny neurons [J].