Assessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines

被引：66

作者：

Richards, EL

Murphy, PJ ^{[1
]}

Dinon, F

Fratucello, S

Brown, PM

Gelbrich, T

Hursthouse, MB

机构：

[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales

[2] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 36期

基金：

英国工程与自然科学研究理事会;

关键词：

tandem Michael/intramolecular aldol reaction; secondary amine; thiols; phosphines;

D O I：

10.1016/S0040-4020(01)00744-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5-7 membered rings. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7771 / 7784

页数：14

共 23 条

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