Carnosine and taurine protect rat cerebellar granular cells from free radical damage

被引：63

作者：

Boldyrev, AA

Johnson, P ^{[1
]}

Wei, YZ

Tan, YS

Carpenter, DO

机构：

[1] Ohio Univ, Dept Biochem & Chem, Athens, OH 45701 USA

[2] Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA

[3] Moscow MV Lomonosov State Univ, Ctr Biotechnol, Dept Biochem, Moscow 119899, Russia

[4] Moscow MV Lomonosov State Univ, Ctr Mol Med, Dept Biochem, Moscow 119899, Russia

[5] Ohio Univ, Edison Anim Biotechnol Ctr, Athens, OH 45701 USA

[6] Univ Albany, Sch Publ Hlth, Rensselaer, NY 12144 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 263卷 / 2-3期

关键词：

kainic acid; 3-morpholinosydnonimine hydrochloride; free radicals; carnosine; taurine; neuron;

D O I：

10.1016/S0304-3940(99)00150-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Carnosine and taurine have been suggested to protect excitable tissues against oxidative stress. We have investigated the protection of cerebellar granule cells (neurons) by these compounds against free radicals generated by kainic acid (KA), and 3-morpholinosydnonimine hydrochloride (SIN-1) treatment. Carnosine decreased free radical levels in KA and SIN-1 treated cells, and increased cell viability. The KA effect, but not that of SIN-I, was dependent on the presence of external Ca2+ ions. Taurine increased cell viability, but did not decrease free radical levers. These results suggest that there are multiple pathways leading to cell death, not all of which involve decreases in intracellular free radical levels, and also indicate that multiple mechanisms of cellular defense exist against oxidative stress. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 172

页数：4

共 21 条

[1] Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: An in vivo microdialysis study [J].