Value of SPIO for MRI of the bone marrow before and after Total Body Irradiation (TBI) -: Initial investigations in an animal model.

被引:6
作者
Daldrup-Link, HE
Reinländer, C
Link, TM
Richter, KJ
Könemann, S
Rummeny, EJ
机构
[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Rontgendiagnost, D-81675 Munich, Germany
[2] Univ Munster, Inst Klin Radiol, D-4400 Munster, Germany
[3] Univ Munster, Klin & Poliklin Strahlentherapie, D-4400 Munster, Germany
[4] Univ Munster, Zent Tierexpt Einrichtung, D-4400 Munster, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2001年 / 173卷 / 06期
关键词
MR-contrast agents; SPIO; bone marrow; Total Body Irradiation (TBI);
D O I
10.1055/s-2001-14989
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: Evaluation of the value of superparamagnetic iron oxides (SPIO; Endorem (R)) for MRI-derived quantifications of the permeability of the blood-bone marrow barrier and the phagocytic activity of reticuloendothelial system (RES) bone marrow cells before and after TBI. Methods: 12 New Zealand white rabbits underwent MRI of the lumbar spine and os sacrum using T-1-weighted spinecho (SE) and T-2-weighted Turbo-SE (TSE) sequences before and after injection of SPIO (Endorem (R)). Four animals each were examined without irradiation, after 4 Gy total body irradiation (TBI), and after 12 Gy TBI. Changes in bone marrow signal intensities (SI) after contrast agent injection were quantified as Delta SI(%) = / ((SIpost-SIpre)/SIpre) x 100% / I and these data were correlated with bone marrow histopathology. Results: Histopathology of the bone marrow revealed a radiation-induced decline of all hematopoetic cell lines. SPIO were phagocytosed by bone marrow RES cells and caused a significant bone marrow signal decline on postcontrast T-2-weighted images (p <0.05). Delta SI(%) data for T-2-weighted images were significantly higher for the irradiated bone marrow as compared to non-irradiated controls (p <0.05). Dynamic T-1-weighted images directly after contrast medium injection were not able to characterize the permeability of the blood-bone marrow barrier. Conclusion: Hematopoetic bone marrow can be labelled with SPIO. Irradiation does not impair the phagocytic activity of bone marrow RES cells. However, the bone marrow enhancement with SPIO is smaller as compared to previous results obtained by our group with USPIO.
引用
收藏
页码:547 / 553
页数:7
相关论文
共 26 条
  • [1] DETECTION OF VERTEBRAL METASTASES - COMPARISON BETWEEN MR IMAGING AND BONE-SCINTIGRAPHY
    ALGRA, PR
    BLOEM, JL
    TISSING, H
    FALKE, THM
    ARNDT, JW
    VERBOOM, LJ
    [J]. RADIOGRAPHICS, 1991, 11 (02) : 219 - 232
  • [2] LIVER METASTASES - SAFETY AND EFFICACY OF DETECTION WITH SUPERPARAMAGNETIC IRON-OXIDE IN MR-IMAGING
    BELLIN, MF
    ZAIM, S
    AUBERTON, E
    SARFATI, G
    DURON, JJ
    KHAYAT, D
    GRELLET, J
    [J]. RADIOLOGY, 1994, 193 (03) : 657 - 663
  • [3] BRASCH RC, 1992, RADIOLOGY, V183, P1
  • [4] SUPERPARAMAGNETIC IRON-OXIDES AS POSITIVE MR CONTRAST AGENTS - INVITRO AND INVIVO EVIDENCE
    CHAMBON, C
    CLEMENT, O
    LEBLANCHE, A
    SCHOUMANCLAEYS, E
    FRIJA, G
    [J]. MAGNETIC RESONANCE IMAGING, 1993, 11 (04) : 509 - 519
  • [5] BONE-MARROW PERFUSION EVALUATED WITH GADOLINIUM-ENHANCED DYNAMIC FAST MR IMAGING IN A DOG-MODEL
    COVA, M
    KANG, YS
    TSUKAMOTO, H
    JONES, LC
    MCVEIGH, E
    NEFF, BL
    HEROLD, CJ
    SCOTT, WW
    HUNGERFORD, DS
    ZERHOUNI, EA
    [J]. RADIOLOGY, 1991, 179 (02) : 535 - 539
  • [6] Daldrup HE, 1999, JMRI-J MAGN RESON IM, V9, P643, DOI 10.1002/(SICI)1522-2586(199905)9:5<643::AID-JMRI5>3.0.CO
  • [7] 2-A
  • [8] Assessing permeability alterations of the blood-bone marrow barrier due to total body irradiation:: in vivo quantification with contrast enhanced magnetic resonance imaging
    Daldrup-Link, HE
    Link, TM
    Rummeny, EJ
    August, C
    Könemann, S
    Jürgens, H
    Heindel, W
    [J]. BONE MARROW TRANSPLANTATION, 2000, 25 (01) : 71 - 78
  • [9] Daldrup-Link HE, 2000, RADIOLOGY, V217, P356
  • [10] BONE-MARROW MRI - TECHNIQUES AND ACCURACY FOR DETECTING BREAST-CANCER METASTASES
    FLICKINGER, FW
    SANAL, SM
    [J]. MAGNETIC RESONANCE IMAGING, 1994, 12 (06) : 829 - 835