MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia

被引：54

作者：

Gao, Xiao-ning ^{[1
]}

Lin, Ji ^{[2
]}

Gao, Li ^{[1
]}

Li, Yong-hui ^{[1
]}

Wang, Li-li ^{[1
]}

Yu, Li ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing 100853, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Basic Med Inst, Beijing 100853, Peoples R China

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 09期

基金：

中国国家自然科学基金;

关键词：

MicroRNA; miR-193b; c-Kit; Acute myeloid leukemia; RECEPTOR TYROSINE KINASES; FUNCTIONAL-ROLE; BREAST-CANCER; EXPRESSION; MUTATIONS; MALIGNANCIES; CONTRIBUTES; INHIBITION; SUNITINIB; APOPTOSIS;

D O I：

10.1016/j.leukres.2011.06.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1226 / 1232

页数：7

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