The MET receptor tyrosine kinase in invasion and metastasis

被引：210

作者：

Benvenuti, Silvia ^{[1
]}

Comoglio, Paolo M. ^{[1
]}

机构：

[1] Univ Turin, IRCCS, Sch Med, Inst Canc Res & Treatment,Div Mol Oncol, I-10060 Candiolo, Torino, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 213卷 / 02期

关键词：

D O I：

10.1002/jcp.21183

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON.

引用

收藏

页码：316 / 325

页数：10

相关论文

共 122 条

[1] Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation [J].

Abella, JV ;

Peschard, P ;

Naujokas, MA ;

Lin, T ;

Saucier, C ;

Urbé, S ;

Park, M .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (21) :9632-9645

[2] The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation [J].

Angeloni, D ;

Danilkovitch-Miagkova, A ;

Miagkov, A ;

Leonard, EJ ;

Lerman, MI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (05) :3726-3732

[3] Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression [J].

Bardella, C ;

Costa, B ;

Maggiora, P ;

Patane, S ;

Olivero, M ;

Ranzani, GN ;

De Bortoli, M ;

Comoglio, PM ;

Di Renzo, MF .

CANCER RESEARCH, 2004, 64 (15) :5154-5161

[4] Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth [J].

Bardelli, A ;

Longati, P ;

Gramaglia, D ;

Basilico, C ;

Tamagnone, L ;

Giordano, S ;

Ballinari, D ;

Michieli, P ;

Comoglio, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14379-14383

[5] Venous thromboembolism and cancer [J].

Baron, JA ;

Gridley, G ;

Weiderpass, E ;

Nyrén, O ;

Linet, M .

LANCET, 1998, 351 (9109) :1077-1080

[6] Epidermal growth factor receptor signaling activates Met in human anaplastic thyroid carcinoma cells [J].

Bergström, JD ;

Westermark, B ;

Heldin, NE .

EXPERIMENTAL CELL RESEARCH, 2000, 259 (01) :293-299

[7] The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants [J].

Berthou, S ;

Aebersold, DM ;

Schmidt, LS ;

Stroka, D ;

Heigl, C ;

Streit, B ;

Stalder, D ;

Gruber, G ;

Liang, CX ;

Howlett, AR ;

Candinas, D ;

Greiner, RH ;

Lipson, KE ;

Zimmer, Y .

ONCOGENE, 2004, 23 (31) :5387-5393

[8]

BEZERRA JA, 1993, PROTEIN SCI, V2, P666

[9] Stromal fibroblasts in cancer initiation and progression [J].

Bhowmick, NA ;

Neilson, EG ;

Moses, HL .

NATURE, 2004, 432 (7015) :332-337

[10] Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase [J].

Birchmeier, C ;

Gherardi, E .

TRENDS IN CELL BIOLOGY, 1998, 8 (10) :404-410

← 1 2 3 4 5 6 7 8 9 10 →