The MET receptor tyrosine kinase in invasion and metastasis

被引:210
作者
Benvenuti, Silvia [1 ]
Comoglio, Paolo M. [1 ]
机构
[1] Univ Turin, IRCCS, Sch Med, Inst Canc Res & Treatment,Div Mol Oncol, I-10060 Candiolo, Torino, Italy
关键词
D O I
10.1002/jcp.21183
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON.
引用
收藏
页码:316 / 325
页数:10
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