The MET receptor tyrosine kinase in invasion and metastasis

被引:210
作者
Benvenuti, Silvia [1 ]
Comoglio, Paolo M. [1 ]
机构
[1] Univ Turin, IRCCS, Sch Med, Inst Canc Res & Treatment,Div Mol Oncol, I-10060 Candiolo, Torino, Italy
关键词
D O I
10.1002/jcp.21183
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or extracellular matrix (EMC)). Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON.
引用
收藏
页码:316 / 325
页数:10
相关论文
共 122 条
[61]   The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the Met receptor tyrosine kinase [J].
Maroun, CR ;
Naujokas, MA ;
Holgado-Madruga, M ;
Wong, AJ ;
Park, M .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (22) :8513-8525
[62]   NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics [J].
Matsumoto, K ;
Nakamura, T .
CANCER SCIENCE, 2003, 94 (04) :321-327
[63]   An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice [J].
Mazzone, M ;
Basilico, C ;
Cavassa, S ;
Pennacchietti, S ;
Risio, M ;
Naldini, L ;
Comoglio, PM ;
Michieli, P .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1418-1432
[64]   Targeting the tumor and its microenvironment by a dual-function decoy Met receptor [J].
Michieli, P ;
Mazzone, M ;
Basilico, C ;
Cavassa, S ;
Sottile, A ;
Naldini, L ;
Comoglio, PM .
CANCER CELL, 2004, 6 (01) :61-73
[65]   Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma [J].
Miller, CT ;
Lin, L ;
Casper, AM ;
Lim, J ;
Thomas, DG ;
Orringer, MB ;
Chang, AC ;
Chambers, AF ;
Giordano, TJ ;
Glover, TW ;
Beer, DG .
ONCOGENE, 2006, 25 (03) :409-418
[66]   IDENTIFICATION OF A FIBROBLAST-DERIVED EPITHELIAL MORPHOGEN AS HEPATOCYTE GROWTH-FACTOR [J].
MONTESANO, R ;
MATSUMOTO, K ;
NAKAMURA, T ;
ORCI, L .
CELL, 1991, 67 (05) :901-908
[67]   MET receptor is overexpressed but not mutated in oral squamous cell carcinomas [J].
Morello, S ;
Olivero, M ;
Aimetti, M ;
Bernardi, M ;
Berrone, S ;
Di Renzo, MF ;
Giordano, S .
JOURNAL OF CELLULAR PHYSIOLOGY, 2001, 189 (03) :285-290
[68]   Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study [J].
Moroni, M ;
Veronese, S ;
Benvenuti, S ;
Marrapese, G ;
Sartore-Bianchi, A ;
Di Nicolantonio, F ;
Gambacorta, M ;
Siena, S ;
Bardelli, A .
LANCET ONCOLOGY, 2005, 6 (05) :279-286
[69]   K252a inhibits the oncogenic properties of Met, the HGF receptor [J].
Morotti, A ;
Mila, S ;
Accornero, P ;
Tagliabue, E ;
Ponzetto, C .
ONCOGENE, 2002, 21 (32) :4885-4893
[70]   The Ron STK receptor tyrosine kinase is essential for peri-implantation development in the mouse [J].
Muraoka, RS ;
Sun, WY ;
Colbert, MC ;
Waltz, SE ;
Witte, DP ;
Degen, JL ;
Degen, SJF .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (09) :1277-1285