Controlled assembly of macromolecular β-sheet fibrils

被引:124
作者
Smeenk, JM
Otten, MBJ
Thies, J
Tirrell, DA
Stunnenberg, HG
van Hest, JCM
机构
[1] Radboud Univ Nijmegen, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands
[2] DSM Res & Patents, NL-6160 MD Geleen, Netherlands
[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
[4] Univ Nijmegen, Dept Mol Biol, NL-6500 HB Nijmegen, Netherlands
关键词
conjugation; fibers; peptides; polymers; self-assembly;
D O I
10.1002/anie.200462415
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:1968 / 1971
页数:4
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