Controlled assembly of macromolecular β-sheet fibrils

被引：124

作者：

Smeenk, JM

Otten, MBJ

Thies, J

Tirrell, DA

Stunnenberg, HG

van Hest, JCM

机构：

[1] Radboud Univ Nijmegen, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands

[2] DSM Res & Patents, NL-6160 MD Geleen, Netherlands

[3] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[4] Univ Nijmegen, Dept Mol Biol, NL-6500 HB Nijmegen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期

关键词：

conjugation; fibers; peptides; polymers; self-assembly;

D O I：

10.1002/anie.200462415

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1968 / 1971

页数：4

共 19 条

[1] Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes [J].