Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?

被引：101

作者：

Mazella, J ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UPR 0411, F-06560 Valbonne, France

来源：

CELLULAR SIGNALLING | 2001年 / 13卷 / 01期

关键词：

neurotensin; sortilin; type I receptor; cellular trafficking; neuropeptide; signaling;

D O I：

10.1016/S0898-6568(00)00130-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of gp95sortilin, a sorting protein, as being the 100 kDa neurotensin (NT) receptor, a non-G-protein coupled receptor, constitutes a new and interesting but intriguing step in the neuropeptide signaling as well as in cellular trafficking. The isolation of the same protein by three different experimental approaches sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3). This review will concentrate on the putative physiological and cellular roles of sortilin/NTR3 as most results so far have proposed hypothetical conclusions rather than concrete evidence. © 2001 Elsevier Science Inc.

引用

页码：1 / 6

页数：6

共 48 条

[1] PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells [J].

Barbero, P ;

Rovère, C ;

De Bie, I ;

Seidah, N ;

Beaudet, A ;

Kitabgi, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (39) :25339-25346

[2] DO ANTIDEPRESSANTS STABILIZE MOOD THROUGH ACTIONS ON THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL SYSTEM [J].

BARDEN, N ;

REUL, JMHM ;

HOLSBOER, F .

TRENDS IN NEUROSCIENCES, 1995, 18 (01) :6-11

[3]

BATTEY FD, 1994, J BIOL CHEM, V269, P23268

[4] Nonpeptide antagonists of neuropeptide receptors: tools for research and therapy [J].

Betancur, C ;

Azzi, M ;

Rostene, W .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (10) :372-386

[5] Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: Agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor [J].

Botto, JM ;

Guillemare, E ;

Vincent, JP ;

Mazella, J .

NEUROSCIENCE LETTERS, 1997, 223 (03) :193-196

[6] 39-KDA RECEPTOR-ASSOCIATED PROTEIN IS AN ER RESIDENT PROTEIN AND MOLECULAR CHAPERONE FOR LDL RECEPTOR-RELATED PROTEIN [J].

BU, GJ ;

GEUZE, HJ ;

STROUS, GJ ;

SCHWARTZ, AL .

EMBO JOURNAL, 1995, 14 (10) :2269-2280

[7]

CHABRY J, 1993, J BIOL CHEM, V268, P17138

[8]

CHABRY J, 1994, J NEUROCHEM, V63, P19

[9] Molecular cloning of a levocabastine-sensitive neurotensin binding site [J].

Chalon, P ;

Vita, N ;

Kaghad, M ;

Guillemot, M ;

Bonnin, J ;

Delpech, B ;

LeFur, G ;

Ferrara, P ;

Caput, D .

FEBS LETTERS, 1996, 386 (2-3) :91-94

[10] MULTILIGAND ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN (ALPHA(2)MR/LRP) - BINDING AND ENDOCYTOSIS OF FLUID-PHASE AND MEMBRANE-ASSOCIATED LIGANDS [J].

GLIEMANN, J ;

NYKJAER, A ;

PETERSEN, CM ;

JORGENSEN, KE ;

NIELSEN, M ;

ANDREASEN, PA ;

CHRISTENSEN, EI ;

LOOKENE, A ;

OLIVECRONA, G ;

MOESTRUP, SK .

BIOLOGY OF ALPHA2-MACROGLOBULIN, ITS RECEPTOR, AND RELATED PROTEINS, 1994, 737 :20-38

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