Recent human-specific spreading of a subtelomeric domain

被引：33

作者：

Monfouilloux, S

Avet-Loiseau, H

Amarger, V

Balazs, I

Pourcel, C

Vergnaud, G

机构：

[1] Hop Nantes, Inst Biol, Lab Rech Genet Especes, F-44035 Nantes, France

[2] Hop Nantes, Inst Biol, UF Cytogenet Hematol, F-44035 Nantes, France

[3] Lifecodes Corp, Stamford, CT 06902 USA

[4] Inst Pasteur, Unite Immunohematol, F-75724 Paris, France

[5] Ctr Etud Bouchet, Genet Mol Lab, F-91710 Vert Le Petit, France

来源：

GENOMICS | 1998年 / 51卷 / 02期

关键词：

D O I：

10.1006/geno.1998.5358

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The recent spreading of a subtelomeric region at nine different human chromosome ends was characterized by a combination of segregation analyses, physical mapping, junction cloning, and FISH investigations. The events occurred very recently in human genome evolution as demonstrated by sequence analysis of different alleles and the single location of the ancestral site at chromosome 17qter in chimpanzee and orangutan. The domain successfully colonized most Ip, 5q, and 6q chromosome ends and is also present at a significant frequency of Gp, 7p, 8p, lip, 15q, and 19p ends. On 6qter, the transposed domain is immediately distal to the highly conserved, single-copy gene PDCD2. (C) 1998 Academic Press.

引用

页码：165 / 176

页数：12

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