Division of labor, plasticity, and crosstalk between dendritic cell subsets

被引：112

作者：

Pulendran, Bali ^{[1
,2
]}

Tang, Hua ^{[1
]}

Denning, Timothy L. ^{[1
]}

机构：

[1] Emory Vaccine Ctr, Atlanta, GA 30329 USA

[2] Dept Pathol, Atlanta, GA 30329 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 01期

关键词：

D O I：

10.1016/j.coi.2007.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For years, dendritic cell (DC) biologists have oscillated between two seemingly antagonistic ideas: functional specialization (division of labor) of DC subsets and plasticity (multitasking). More recently, a third hypothesis is gathering support: crosstalk between functionally distinct DC subsets. This reveals a previously unappreciated hierarchy of organization within the DC system, and provides a conceptual framework to understand how cooperation between functionally distinct, yet plastic, DC subsets can shape adaptive immunity and immunological memory. Here we review the recent advances in this area.

引用

页码：61 / 67

页数：7

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