Mapping of birefringence and thermal damage in tissue by use of polarization-sensitive optical coherence tomography

被引：118

作者：

Schoenenberger, K ^{[1
]}

Colston, BW ^{[1
]}

Maitland, DJ ^{[1
]}

Da Silva, LB ^{[1
]}

Everett, MJ ^{[1
]}

机构：

[1] Lawrence Livermore Natl Lab, Med Technol Program, Livermore, CA 94550 USA

来源：

APPLIED OPTICS | 1998年 / 37卷 / 25期

关键词：

D O I：

10.1364/AO.37.006026

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate cross-sectional birefringence- and polarization-independent backscatter imaging of laser-induced thermal damage in porcine myocardium in vitro, using a polarization-sensitive optical coherence tomography system. We compare the generated images with histological sections of the tissue and demonstrate that birefringence is a more sensitive indicator of thermal damage than is backscattered Light. Loss of birefringence in thermally damaged regions is quantified and shown to have significant contrast with undamaged sections of the tissue. A detailed theoretical analysis of the birefringence measurements is provided, including a calculation of the systematic errors associated with background noise, system imperfections, and tissue dichroism. (C) 1998 Optical Society of America.

引用

页码：6026 / 6036

页数：11

共 23 条

[1] Laser tissue welding: A comprehensive review of current and future clinical applications [J].

Bass, LS ;

Treat, MR .

LASERS IN SURGERY AND MEDICINE, 1995, 17 (04) :315-349

[2] BIREFRINGENCE OF THE HUMAN FOVEAL AREA ASSESSED INVIVO WITH MUELLER-MATRIX ELLIPSOMETRY [J].

BRINK, HBK ;

VANBLOKLAND, GJ .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1988, 5 (01) :49-57

[3]

BROSSEAU C, 1996, OSA TRENDS OPTICS PH, V2, P50

[4] OPTICAL ROTATION AND HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN COLLAGEN AND GELATIN [J].

COHEN, C .

JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY, 1955, 1 (03) :203-214

[5]

COLLETT E, 1993, OPTICAL ENG SERIES, V36

[6] Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography [J].

deBoer, JF ;

Milner, TE ;

vanGemert, MJC ;

Nelson, JS .

OPTICS LETTERS, 1997, 22 (12) :934-936

[7] Birefringence characterization of biological tissue by use of optical coherence tomography [J].

Everett, MJ ;

Schoenenberger, K ;

Colston, BW ;

Da Silva, LB .

OPTICS LETTERS, 1998, 23 (03) :228-230

[8] POLARIZATION-SENSITIVE LOW-COHERENCE REFLECTOMETER FOR BIREFRINGENCE CHARACTERIZATION AND RANGING [J].

HEE, MR ;

HUANG, D ;

SWANSON, EA ;

FUJIMOTO, JG .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 1992, 9 (06) :903-908

[9] Laser skin resurfacing [J].

Hruza, GJ ;

Dover, JS .

ARCHIVES OF DERMATOLOGY, 1996, 132 (04) :451-455

[10] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

← 1 2 3 →