Novel method for depth-resolved brain functional imaging by time-domain NIRS

被引：34

作者：

Contini, Davide ^{[1
]}

Spinelli, Lorenzo ^{[1
]}

Torricelli, Alessandro ^{[1
]}

Pifferi, Antonio ^{[1
]}

Cubeddu, Rinaldo ^{[1
]}

机构：

[1] ULTRAS INFM CNR, IIT, Piazza Leonardo Da Vinci 32, I-20133 Milan, Italy

来源：

DIFFUSE OPTICAL IMAGING OF TISSUE | 2007年 / 6629卷

关键词：

photon migration; medical optics instrumentation; time-resolved imaging; blood/tissue constituent monitoring;

D O I：

10.1117/12.728104

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A novel approach to improve depth selectivity based on time-domain contrast functions is presented. The method was tested with Monte Carlo simulations showing sensitivity to absorption changes of deep inclusions and improved rejection of superficial effects. Preliminary in-vivo measurements were performed on healthy volunteer during a Valsalva maneuver and during finger tapping discriminating brain cortex activation from hemodynamic changes associated to systemic effects in the scalp.

引用

页数：7

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