Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs.

被引：11

作者：

Demaison, C

Hourioux, C

Roingeard, P

Agrofoglio, LA ^{[1
]}

机构：

[1] Fac Sci, CNRS, ICOA, F-45100 Orleans, France

[2] CHU Bretonneau, Lab Virol & Biol Cellulaire, CNRS, EP 117, F-37044 Tours, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(98)02137-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of hitherto unknown carbocyclic alpha-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：9175 / 9178

页数：4

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