The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development

被引：107

作者：

Knippschild, U ^{[1
]}

Wolff, S ^{[1
]}

Giamas, G ^{[1
]}

Brockschmidt, C ^{[1
]}

Wittau, M ^{[1
]}

Würl, PU ^{[1
]}

Eismann, T ^{[1
]}

Stöter, M ^{[1
]}

机构：

[1] Univ Ulm, Abt Viszeral & Transplantat Chirurg, D-89075 Ulm, Germany

来源：

ONKOLOGIE | 2005年 / 28卷 / 10期

关键词：

CK1; p53; Wnt; spindle dynamics; centrosome;

D O I：

10.1159/000087137

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Mutations and deregulation of CK1 expression and activity has been linked to various diseases including neurodegenerative disorders such as Alzheimer's and Parkinson's disease, sleeping disorders and proliferative diseases such as cancer. In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development.

引用

页码：508 / 514

页数：7

共 80 条

[51] Catalytic activity of protein kinase CK1δ (casein kinase 1δ) is essential for its normal subcellular localization [J].