National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

被引：1398

作者：

Montine, Thomas J. ^{[1
]}

Phelps, Creighton H. ^{[2
]}

Beach, Thomas G. ^{[3
]}

Bigio, Eileen H. ^{[4
,5
]}

Cairns, Nigel J. ^{[6
,7
]}

Dickson, Dennis W. ^{[8
]}

Duyckaerts, Charles ^{[9
]}

Frosch, Matthew P. ^{[10
]}

Masliah, Eliezer ^{[11
,12
]}

Mirra, Suzanne S. ^{[13
]}

Nelson, Peter T. ^{[14
]}

Schneider, Julie A. ^{[15
,16
]}

Thal, Dietmar Rudolf ^{[17
]}

Trojanowski, John Q. ^{[18
]}

Vinters, Harry V. ^{[19
,20
]}

Hyman, Bradley T. ^{[21
]}

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98104 USA

[2] NIA, Bethesda, MD 20892 USA

[3] Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ USA

[4] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Northwestern Univ, NW Alzheimer Dis Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[8] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[9] Hop La Pitie Salpetriere, Serv Neuropathol Raymond Escourolle, Paris, France

[10] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA USA

[11] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[12] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

[13] Suny Downstate Med Ctr, Dept Pathol, Brooklyn, NY 11203 USA

[14] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[15] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[16] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[17] Univ Ulm, Neuropathol Lab, Inst Pathol, Ulm, Germany

[18] Univ Penn, Sch Med, Dept Pathol & Lab Med, Inst Aging,Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[19] Univ Calif Los Angeles, Dept Pathol & Lab Med Neuropathol, Los Angeles, CA USA

[20] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[21] Harvard Univ, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

来源：

ACTA NEUROPATHOLOGICA | 2012年 / 123卷 / 01期

关键词：

BRAINNET EUROPE CONSORTIUM; LEWY BODY DISEASE; FRONTOTEMPORAL LOBAR DEGENERATION; VASCULAR COGNITIVE IMPAIRMENT; CEREBRAL AMYLOID ANGIOPATHY; HIPPOCAMPAL SCLEROSIS; DIAGNOSTIC GUIDELINES; SYNAPSE LOSS; NEUROFIBRILLARY PATHOLOGY; CONSENSUS RECOMMENDATIONS;

D O I：

10.1007/s00401-011-0910-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid beta deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.

引用

页码：1 / 11

页数：11

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