Convenient approaches to 4-trifluoromethylpyridine

被引：22

作者：

Jiang, B

Xiong, WN

Zhang, XB

Zhang, FJ

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Synica Chem, Chinese Acad Sci, Engn Res Ctr Organ Synth, Shanghai 200062, Peoples R China

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 05期

关键词：

D O I：

10.1021/op000109r

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A number of approaches to the synthesis of 2-chloro- and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro- and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)-ether in two steps.

引用

页码：531 / 534

页数：4

共 24 条

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