Metabolomics: building on a century of biochemistry to guide human health

被引:254
作者
German, J. Bruce [2 ,3 ]
Hammock, Bruce D. [4 ,5 ]
Watkins, Steven M. [1 ]
机构
[1] Lipom Technol Inc, W Sacramento, CA 95691 USA
[2] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA
[3] Nestle Res Ctr, CH-1000 Lausanne, Switzerland
[4] Univ Calif Davis, Ctr Canc, Davis, CA 95616 USA
[5] Dept Entomol, Davis, CA 95616 USA
关键词
metabolomics; metabolic profiling; human health;
D O I
10.1007/s11306-005-1102-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Medical diagnosis and treatment efficacy will improve significantly when a more personalized system for health assessment is implemented. This system will require diagnostics that provide sufficiently detailed information about the metabolic status of individuals such that assay results will be able to guide food, drug and lifestyle choices to maintain or improve distinct aspects of health without compromising others. Achieving this goal will use the new science of metabolomics - comprehensive metabolic profiling of individuals linked to the biological understanding of human integrative metabolism. Candidate technologies to accomplish this goal are largely available, yet they have not been brought into practice for this purpose. Metabolomic technologies must be sufficiently rapid, accurate and affordable to be routinely accessible to both healthy and acutely ill individuals. The use of metabolomic data to predict the health trajectories of individuals will require bioinformatic tools and quantitative reference databases. These databases containing metabolite profiles from the population must be built, stored and indexed according to metabolic and health status. Building and annotating these databases with the knowledge to predict how a specific metabolic pattern from an individual can be adjusted with diet, drugs and lifestyle to improve health represents a logical application of the biochemistry knowledge that the life sciences have produced over the past 100 years.
引用
收藏
页码:3 / 9
页数:7
相关论文
共 26 条
[1]  
Alberti G, 2001, B WORLD HEALTH ORGAN, V79, P907
[2]  
Brindle JT, 2002, NAT MED, V8, P1439, DOI 10.1038/nm802
[3]   Perspectives in cholesterol-lowering therapy - The role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption [J].
Bruckert, E ;
Giral, P ;
Tellier, P .
CIRCULATION, 2003, 107 (25) :3124-3128
[4]   A short history of nutritional science: Part 4 (1945-1985) [J].
Carpenter, KJ .
JOURNAL OF NUTRITION, 2003, 133 (11) :3331-3342
[5]   A short history of nutritional science: Part 3 (1912-1944) [J].
Carpenter, KJ .
JOURNAL OF NUTRITION, 2003, 133 (10) :3023-3032
[6]   An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry [J].
Castrillo, JI ;
Hayes, A ;
Mohammed, S ;
Gaskell, SJ ;
Oliver, SG .
PHYTOCHEMISTRY, 2003, 62 (06) :929-937
[7]   A vision for the future of genomics research [J].
Collins, FS ;
Green, ED ;
Guttmacher, AE ;
Guyer, MS .
NATURE, 2003, 422 (6934) :835-847
[8]   Metabolic networks of Cucurbita maxima phloem [J].
Fiehn, O .
PHYTOCHEMISTRY, 2003, 62 (06) :875-886
[9]  
Grundy SM, 2002, AM J CARDIOL, V90, p11I
[10]   Systems biology: integrating technology, biology, and computation [J].
Hood, L .
MECHANISMS OF AGEING AND DEVELOPMENT, 2003, 124 (01) :9-16