Systems biology: integrating technology, biology, and computation

被引:172
作者
Hood, L [1 ]
机构
[1] Inst Syst Biol, Seattle, WA 98103 USA
关键词
systems biology; biological information; genomics; proteomics; galactose utilization system; predictive; preventive; and personalized medicine;
D O I
10.1016/S0047-6374(02)00164-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Human Genome Project has changed the worlds of biology and medicine-helping to catalyze two major paradigm changes: systems biology and predictive, preventive and personalized medicine. These two themes will dominate 21st century biology and medicine. I will discuss these changes and indicate how they may interface with with the process of aging. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:9 / 16
页数:8
相关论文
共 10 条
[1]   High-density oligonucleotide arrays [J].
Blanchard, AP ;
Kaiser, RJ ;
Hood, LE .
BIOSENSORS & BIOELECTRONICS, 1996, 11 (6-7) :687-690
[2]   Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays [J].
Brenner, S ;
Johnson, M ;
Bridgham, J ;
Golda, G ;
Lloyd, DH ;
Johnson, D ;
Luo, SJ ;
McCurdy, S ;
Foy, M ;
Ewan, M ;
Roth, R ;
George, D ;
Eletr, S ;
Albrecht, G ;
Vermaas, E ;
Williams, SR ;
Moon, K ;
Burcham, T ;
Pallas, M ;
DuBridge, RB ;
Kirchner, J ;
Fearon, K ;
Mao, J ;
Corcoran, K .
NATURE BIOTECHNOLOGY, 2000, 18 (06) :630-634
[3]   Quantitative analysis of complex protein mixtures using isotope-coded affinity tags [J].
Gygi, SP ;
Rist, B ;
Gerber, SA ;
Turecek, F ;
Gelb, MH ;
Aebersold, R .
NATURE BIOTECHNOLOGY, 1999, 17 (10) :994-999
[4]   A personal view of molecular technology and how it has changed biology [J].
Hood, L .
JOURNAL OF PROTEOME RESEARCH, 2002, 1 (05) :399-409
[5]  
HOOD L, 2003, IN PRESS NATURE
[6]   A new approach to decoding life: Systems biology [J].
Ideker, T ;
Galitski, T ;
Hood, L .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2001, 2 :343-372
[7]   Integrated genomic and proteomic analyses of a systematically perturbed metabolic network [J].
Ideker, T ;
Thorsson, V ;
Ranish, JA ;
Christmas, R ;
Buhler, J ;
Eng, JK ;
Bumgarner, R ;
Goodlett, DR ;
Aebersold, R ;
Hood, L .
SCIENCE, 2001, 292 (5518) :929-934
[8]   Initial sequencing and analysis of the human genome [J].
Lander, ES ;
Int Human Genome Sequencing Consortium ;
Linton, LM ;
Birren, B ;
Nusbaum, C ;
Zody, MC ;
Baldwin, J ;
Devon, K ;
Dewar, K ;
Doyle, M ;
FitzHugh, W ;
Funke, R ;
Gage, D ;
Harris, K ;
Heaford, A ;
Howland, J ;
Kann, L ;
Lehoczky, J ;
LeVine, R ;
McEwan, P ;
McKernan, K ;
Meldrim, J ;
Mesirov, JP ;
Miranda, C ;
Morris, W ;
Naylor, J ;
Raymond, C ;
Rosetti, M ;
Santos, R ;
Sheridan, A ;
Sougnez, C ;
Stange-Thomann, N ;
Stojanovic, N ;
Subramanian, A ;
Wyman, D ;
Rogers, J ;
Sulston, J ;
Ainscough, R ;
Beck, S ;
Bentley, D ;
Burton, J ;
Clee, C ;
Carter, N ;
Coulson, A ;
Deadman, R ;
Deloukas, P ;
Dunham, A ;
Dunham, I ;
Durbin, R ;
French, L .
NATURE, 2001, 409 (6822) :860-921
[9]   FLUORESCENCE DETECTION IN AUTOMATED DNA-SEQUENCE ANALYSIS [J].
SMITH, LM ;
SANDERS, JZ ;
KAISER, RJ ;
HUGHES, P ;
DODD, C ;
CONNELL, CR ;
HEINER, C ;
KENT, SBH ;
HOOD, LE .
NATURE, 1986, 321 (6071) :674-679
[10]   The sequence of the human genome [J].
Venter, JC ;
Adams, MD ;
Myers, EW ;
Li, PW ;
Mural, RJ ;
Sutton, GG ;
Smith, HO ;
Yandell, M ;
Evans, CA ;
Holt, RA ;
Gocayne, JD ;
Amanatides, P ;
Ballew, RM ;
Huson, DH ;
Wortman, JR ;
Zhang, Q ;
Kodira, CD ;
Zheng, XQH ;
Chen, L ;
Skupski, M ;
Subramanian, G ;
Thomas, PD ;
Zhang, JH ;
Miklos, GLG ;
Nelson, C ;
Broder, S ;
Clark, AG ;
Nadeau, C ;
McKusick, VA ;
Zinder, N ;
Levine, AJ ;
Roberts, RJ ;
Simon, M ;
Slayman, C ;
Hunkapiller, M ;
Bolanos, R ;
Delcher, A ;
Dew, I ;
Fasulo, D ;
Flanigan, M ;
Florea, L ;
Halpern, A ;
Hannenhalli, S ;
Kravitz, S ;
Levy, S ;
Mobarry, C ;
Reinert, K ;
Remington, K ;
Abu-Threideh, J ;
Beasley, E .
SCIENCE, 2001, 291 (5507) :1304-+