Microbial transformation of dehydroepiandrosterone

被引：32

作者：

Choudhary, MI ^{[1
]}

Shah, SAA ^{[1
]}

Musharraf, SG ^{[1
]}

Shaheen, F ^{[1
]}

Atta-Ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2003年 / 17卷 / 03期

关键词：

Rhizopus stolonifer; dehydroepiandrosterone ( DHEA); 3; beta; 17; beta-dihydroxyandrost-5-ene; beta-dihydroxyandrost-4-ene; beta-hydroxyandrost-4-ene-3-one; 11; beta-dihydroxyandrost-4-ene-17-one; 7; alpha-dihydroandrost-5-ene-17-one; alpha; beta-trihydroxyandrost-5-ene; 11 beta-hydroxyandrost-4,6-diene-3,17-dione; fungal transformation;

D O I：

10.1080/1057563021000040835

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

Transformation of dehydroepiandrosterone (DHEA) (1) was carried out by a plant pathogen Rhizopus stolonifer, which resulted in the production of seven metabolites. These metabolites were identified as 3beta, 17beta-dihydroxyandrost-5-ene (2), 3beta, 17beta-dihydroxyandrost-4-ene (3), 17beta-hydroxyandrost-4-ene-3-one (4), 3beta,11beta-dihydroxyandrost-4-ene-17-one (5), 3beta,7alpha- dihydroandrost-5-ene-17-one (6), 3beta,7alpha,17beta-trihydroxyandrost-5-ene (7) and 11beta-hydroxyandrost-4,6-diene-3,17-dione (8). The structures of the transformed products were determined by the spectroscopic techniques.

引用

页码：215 / 220

页数：6

共 8 条

[1]

Atta-ur-Rahman, 1998, NAT PROD LETT, V12, P255

[2]

Fungal transformations of steroids by Cephalosporium aphidicola and Trichothecium roseum [J].

Atta-Ur-Rahman ;

Choudhary, MI ;

Asif, F ;

Farooq, A ;

Yaqoob, M .

NATURAL PRODUCT LETTERS, 2000, 14 (03) :217-224

[3]

Microbial transformations of hypolipemic E-guggulsterone [J].

Atta-ur-Rahman ;

Choudhary, MI ;

Shaheen, F ;

Ashraf, M ;

Jahan, S .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04) :428-431

[4]

Atta-ur-Rahman, 1998, J NAT PROD, V61, P1340, DOI 10.1021/np980057n

[5]

Atta-ur-Rahman, 1996, SOLVING PROBLEMS NMR

[6]

MICROBIAL TRANSFORMATIONS OF 7-ALPHA-HYDROXYFRULLANOLIDE [J].

ATTAURRAHMAN ;

CHOUDHARY, MI ;

ATA, A ;

ALAM, M ;

FAROOQ, A ;

PERVEEN, S ;

SHEKHANI, MS ;

AHMED, N .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (09) :1251-1255

[7]

Microbial transformation of sclareolide [J].

AttaurRahman ;

Farooq, A ;

Choudhary, MI .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (10) :1038-1040

[8]

MICROBIOLOGICAL HYDROXYLATION OF STEROIDS .1. PROTON MAGNETIC RESONANCE SPECTRA OF KETONES, ALCOHOLS, AND ACETATES IN ANDROSTANE, PREGNANE, AND CESTRANE SERIES [J].

BRIDGEMA.JE ;

CHERRY, PC ;

CLEGG, AS ;

EVANS, JM ;

JONES, ERH ;

KASAL, A ;

KUMAR, V ;

MEAKINS, GD ;

MORISAWA, Y ;

RICHARDS, EE ;

WOODGATE, PD .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (02) :250-&

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