Mood and anxiety disorders in women with treated hyperthyroidism and ophthalmopathy caused by Graves' disease

被引:63
作者
Bunevicius, R [1 ]
Velickiene, D
Prange, AJ
机构
[1] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
[2] Kaunas Univ Med, Inst Endocrinol, LT-50009 Kaunas, Lithuania
关键词
Graves' disease; mood; anxiety; ophthalmopathy;
D O I
10.1016/j.genhosppsych.2004.10.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To evaluate the prevalence of mood and anxiety disorders in women with treated hyperthyroidism caused by Graves' disease and to compare them with the prevalence of such findings in women without past or present thyroid disease. Methods: Thirty inpatient women with treated hyperthyroidism and ophthalmopathy caused by Graves' disease and 45 women hospitalized for treatment of gynecologic disorders such as abnormal vaginal bleeding, benign tumors or infertility were evaluated for the prevalence of mood and anxiety diagnoses using a standard Mini-International Neuropsychiatric Interview and for mood and anxiety ratings using the Profile of Mood States (POMS). At the time of assessment, it was discovered that 14 of 30 women with treated hyperthyroidism caused by Graves' disease were still hyperthyroid, while 16 women were euthyroid. Results: Significantly greater prevalence of social anxiety disorder, generalized anxiety disorder, major depression and total mood and anxiety disorders, as well as higher symptom scores on the POMS, was found in hyperthyroid women with Graves' disease in comparison with the control group. A prevalence of total anxiety disorder, as well as history of mania or hypomania and lifetime bipolar disorder, but not lifetime unipolar depression, was more frequent in both the euthyroid and the hyperthyroid subgroups of study women in comparison with the control group. Conclusions: These results confirm a high prevalence of mood and anxiety disorders in women with treated hyperthyroidism and ophthalmopathy caused by Graves' disease. Hyperthyroidism plays a major role in psychiatric morbidity in Graves' disease. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:133 / 139
页数:7
相关论文
共 45 条
[31]   Addressing depression in obstetrics/gynecology practice [J].
Scholle, SH ;
Haskett, RF ;
Hanusa, BH ;
Pincus, HA ;
Kupfer, DJ .
GENERAL HOSPITAL PSYCHIATRY, 2003, 25 (02) :83-90
[32]   Reliability and Validity of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) [J].
Sheehan, David V. ;
Sheehan, Kathy H. ;
Shytle, R. Douglas ;
Janavs, Juris ;
Bannon, Yvonne ;
Rogers, Jamison E. ;
Milo, Karen M. ;
Stock, Saundra L. ;
Wilkinson, Berney .
JOURNAL OF CLINICAL PSYCHIATRY, 2010, 71 (03) :313-326
[33]   Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review [J].
Simon, NM ;
Blacker, D ;
Korbly, NB ;
Sharma, SG ;
Worthington, JJ ;
Otto, MW ;
Pollack, MH .
JOURNAL OF AFFECTIVE DISORDERS, 2002, 69 (1-3) :209-217
[34]  
Stern RA, 1996, J NEUROPSYCH CLIN N, V8, P181
[35]   Prevalence of psychiatric disorders in gynecologic outpatients [J].
Sundström, IME ;
Bixo, M ;
Björn, I ;
Åström, M .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2001, 184 (02) :8-13
[36]   Long-term effects of Graves' ophthalmopathy on health-related quality of life [J].
Terwee, C ;
Wakelkamp, I ;
Tan, S ;
Dekker, F ;
Prummel, MF ;
Wiersinga, W .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 146 (06) :751-757
[37]   A PSYCHIATRIC AND NEUROPSYCHOLOGICAL STUDY OF PATIENTS WITH UNTREATED GRAVES-DISEASE [J].
TRZEPACZ, PT ;
MCCUE, M ;
KLEIN, I ;
LEVEY, GS ;
GREENHOUSE, J .
GENERAL HOSPITAL PSYCHIATRY, 1988, 10 (01) :49-55
[38]  
TRZEPACZ PT, 1989, AM J MED, V87, P558
[39]   PSYCHIATRIC AND NEUROPSYCHOLOGICAL RESPONSE TO PROPRANOLOL IN GRAVES-DISEASE [J].
TRZEPACZ, PT ;
MCCUE, M ;
KLEIN, I ;
GREENHOUSE, J ;
LEVEY, GS .
BIOLOGICAL PSYCHIATRY, 1988, 23 (07) :678-688
[40]  
Vanderpump MPJ, 2000, WERNER INGBARS THYRO, P465