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Case-control study of the extended tau gene haplotype in Parkinson's disease

被引：46
作者：
Maraganore, DM
Hernandez, DG
Singleton, AB
Fatter, MJ
McDonnell, SK
Hutton, ML
Hardy, JA
Rocca, WA
机构：
[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Mol Genet Lab, Jacksonville, FL USA
来源：
ANNALS OF NEUROLOGY | 2001年 / 50卷 / 05期
关键词：
D O I：
10.1002/ana.1228
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.
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页码：658 / 661
页数：4
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