p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: Thienyl, furyl, and pyrrolyl ureas

被引：37

作者：

Redman, AM

Johnson, JS

Dally, R

Swartz, S

Wild, H

Paulsen, H

Caringal, Y

Gunn, D

Renick, J

Osterhout, M

Kingery-Wood, J

Smith, RA

Lee, W

Dumas, J

Wilhelm, SM

Housley, TJ

Bhargava, A

Ranges, GE

Shrikhande, A

Young, D

Bombara, M

Scott, WJ

机构：

[1] Bayer Res Ctr, Div Pharmaceut, Dept Chem Res, W Haven, CT 06516 USA

[2] Bayer Res Ctr, Div Pharmaceut, Dept Canc & Osteoporosis Res, W Haven, CT 06516 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)00574-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl, furyl, and pyrrolyl ureas has been identified as potent p38 inhibitors, displaying in vitro activity in the nanomolar range. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9 / 12

页数：4

共 19 条

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