The circadian Clock mutant mouse:: impaired masking response to light

被引:35
作者
Redlin, U
Hattar, S
Mrosovsky, N [1 ]
机构
[1] Univ Toronto, Dept Zool, Toronto, ON M5S 3G5, Canada
[2] Univ Stuttgart, Inst Biol, Dept Anim Physiol, D-70550 Stuttgart, Germany
[3] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
[4] Univ Toronto, Dept Physiol, Toronto, ON M5S 3G5, Canada
[5] Univ Toronto, Dept Psychol, Toronto, ON M5S 3G5, Canada
来源
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY | 2005年 / 191卷 / 01期
基金
加拿大健康研究院;
关键词
rhythms; masking; nonvisual photoreception; Clock mutation; melanopsin;
D O I
10.1007/s00359-004-0570-z
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
Synchronization of an internal clock ( entrainment) and a direct response to light ( masking) are complementary ways of restricting activity of an animal to day or night. The protein CLOCK has an important role in the oscillatory mechanism of mammalian pacemakers. Our data show that it is also involved in masking responses. Mice with the Clock/Clock mutation reduced their wheel running less than wildtypes when given 1-h light pulses of light ( 2 - 1,600 lx) in the night. With dimmer lights (< 2 lx), there were no significant differences between mutant and wildtype mice. Impaired masking responses to light in Clock/Clock mice were confirmed in tests with ultradian light - dark cycles (3.5: 3.5 h and 1: 1 h). Tests with pulses of light longer than 1 h revealed that, although the mutants responded more slowly to light, they sustained the suppression of activity over the course of the 3-h tests better than wildtypes.
引用
收藏
页码:51 / 59
页数:9
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