Semi-synthesis of a protease-activatable collagen targeting probe

被引：8

作者：

Breurken, Monica ^{[1
]}

Lempens, Edith H. M. ^{[1
]}

Meijer, E. W. ^{[1
]}

Merkx, Maarten ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Dept Biomed Engn, Biol Chem Lab, NL-5600 MB Eindhoven, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 28期

关键词：

MATRIX-METALLOPROTEINASE; BINDING;

D O I：

10.1039/c1cc11964h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.

引用

页码：7998 / 8000

页数：3

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