Estrogen protects against 3-methylindole-induced olfactory loss

被引:35
作者
Dhong, HJ [1 ]
Chung, SK
Doty, RL
机构
[1] Sungkyunkwan Univ, Coll Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg,Kangnam Gu, Seoul 135710, South Korea
[2] Univ Penn, Med Ctr, Ctr Smell & Taste, Philadelphia, PA 19104 USA
关键词
estrogen; olfactory function; rat; 3-methylindole;
D O I
10.1016/S0006-8993(99)01241-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Olfactory dysfunction is among the first signs of Alzheimer's disease (AD). Since estrogen therapy may mitigate the cognitive symptoms of AD, we determined whether 17 beta-estradiol (E-2) alters the olfactory discrimination performance of female rats exposed to the olfactotoxicant 3-methylindole (3-MI). Twelve ovariectomized rats received daily injections of E-2 (1 mg/kg i.p.) in corn oil and 10 received daily injections of corn oil alone. Sensory testing occurred on a near-daily basis throughout a 10-week test period, midway in which a single injection of 3-MI was administered (300 mg/kg i.p.). On each pre- and post-3-MI test day, the rats were required to perform a series of successively more difficult odor discrimination tasks until one was reached where < 80% performance was attained. The tasks were between the odor of a 10(-4) v/v concentration of ethyl acetate (EA) and the odor of each of six different concentrations of butanol added to the EA (10(-4), 10(-4.5), 10(-5.0), 10(-5.5), 10(-6.0), 10(-6.5) v/v). Following 3-MI treatment, the performance of the E-2-treated rats was found to be superior to that of the oil-treated mts and to return more quickly to the pre-3 MI baseline, suggesting that high doses of E-2 mitigate 3-MI-induced smell loss in rats. Additional work is needed to determine the physiologic basis of this phenomenon (C) 1999 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:312 / 315
页数:4
相关论文
共 25 条
[11]   Nuclear estrogen receptor-independent neuroprotection by estratrienes: A novel interaction with glutathione [J].
Green, PS ;
Gridley, KE ;
Simpkins, JW .
NEUROSCIENCE, 1998, 84 (01) :7-10
[12]   ESTROGEN REPLACEMENT THERAPY IN OLDER WOMEN - COMPARISONS BETWEEN ALZHEIMERS-DISEASE CASES AND NONDEMENTED CONTROL SUBJECTS [J].
HENDERSON, VW ;
PAGANINIHILL, A ;
EMANUEL, CK ;
DUNN, ME ;
BUCKWALTER, JG .
ARCHIVES OF NEUROLOGY, 1994, 51 (09) :896-900
[13]   ESTROGEN AS A GROWTH-FACTOR TO CENTRAL NERVOUS CELLS - ESTROGEN-TREATMENT PROMOTES DEVELOPMENT OF ACETYLCHOLINESTERASE-POSITIVE BASAL FOREBRAIN NEURONS TRANSPLANTED IN THE ANTERIOR EYE CHAMBER [J].
HONJO, H ;
TAMURA, T ;
MATSUMOTO, Y ;
KAWATA, M ;
OGINO, Y ;
TANAKA, K ;
YAMAMOTO, T ;
UEDA, S ;
OKADA, H .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 41 (3-8) :633-635
[14]   Olfaction in neurodegenerative disease -: A meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases [J].
Mesholam, RI ;
Moberg, PJ ;
Mahr, RN ;
Doty, RL .
ARCHIVES OF NEUROLOGY, 1998, 55 (01) :84-90
[15]   Design and evaluation of an olfactometer for the assessment of 3-methylindole-induced hyposmia [J].
Owens, JG ;
James, RA ;
Moss, OR ;
Morgan, KT ;
Bowman, JR ;
Struve, MF ;
Dorman, DC .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1996, 33 (01) :60-70
[16]   FUNCTIONAL DEFICITS PRODUCED BY 3-METHYLINDOLE-INDUCED OLFACTORY MUCOSAL DAMAGE REVEALED BY A SIMPLE OLFACTORY LEARNING-TASK [J].
PEELE, DB ;
ALLISON, SD ;
BOLON, B ;
PRAH, JD ;
JENSEN, KF ;
MORGAN, KT .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 107 (02) :191-202
[17]   ESTROGEN USE IN POSTMENOPAUSAL WOMEN [J].
PFEFFER, RI .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1977, 105 (01) :21-29
[18]   HORMONAL INFLUENCES ON ODOR DETECTION IN RATS - CHANGES ASSOCIATED WITH ESTROUS-CYCLE, PSEUDOPREGNANCY, OVARIECTOMY, AND ADMINISTRATION OF TESTOSTERONE PROPIONATE [J].
PIETRAS, RJ ;
MOULTON, DG .
PHYSIOLOGY & BEHAVIOR, 1974, 12 (03) :475-491
[19]   Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures [J].
Regan, RF ;
Guo, YP .
BRAIN RESEARCH, 1997, 764 (1-2) :133-140
[20]   Odors of individuality originating from the major histocompatibility complex are masked by diet cues in the urine of rats [J].
Schellinck, HM ;
Slotnick, BM ;
Brown, RE .
ANIMAL LEARNING & BEHAVIOR, 1997, 25 (02) :193-199