Searching for a common centromeric structural motif:: Drosophila centromeric satellite DNAs show propensity to form telomeric-like unusual DNA structures

被引：11

作者：

Abad, JP ^{[1
]}

Villasante, A ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

GENETICA | 2000年 / 109卷 / 1-2期

关键词：

centromere; heterochromatin; non B-DNA structures; Drosophila;

D O I：

10.1023/A:1026546510127

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The molecular basis of centromere formation in a particular chromosomal region is not yet understood. In higher eukaryotes, no specific DNA sequence is required for the assembly of the kinetochore, but similar centromeric chromatins are formed on different centromere DNA sequences. Although epigenesis has been proposed as the main mechanism for centromere specification, DNA recognition must also play a role. Through the analysis of Drosophila centromeric DNA sequences, we found that dodeca satellite and 18HT satellite are able to form unusual DNA structures similar to those formed by telomeric sequences. These findings suggest the existence of a common centromeric structural DNA motif which we feel merits further investigation.

引用

页码：71 / 75

页数：5

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