A highly potent insulin-mimetic zinc(II) complex with a Zn(S2O2) coordination mode:: Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)zinc(II)

被引：19

作者：

Adachi, Y

Yoshida, J

Kodera, Y

Sakurai, H

机构：

[1] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Kyoto 6078414, Japan

[2] Wakunaga Pharmaceut Co Ltd, Healthcare Inst, Hiroshima 7391195, Japan

来源：

CHEMISTRY LETTERS | 2005年 / 34卷 / 05期

关键词：

D O I：

10.1246/cl.2005.656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zn(II) complexes of allixin and its sulfur and N-methyl analogs were newly prepared, and their insulin-mimetic activities were evaluated. Among them, a new bis(1,6-dimethyl3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)- zinc(11) complex exhibited the most potent insulin-mimetic activity (IC50 = 11 mu M) in terms of inhibition of free fatty acid release in adipocytes.

引用

收藏

页码：656 / 657

页数：2

相关论文

共 13 条

[1] A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes [J].

Adachi, Y ;

Yoshida, J ;

Kodera, Y ;

Kato, A ;

Yoshikawa, Y ;

Kojima, Y ;

Sakurai, H .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2004, 9 (07) :885-893

[2]

HOYOKU N, 1992, Patent No. 5093505

[3] An extremely high insulin-mimetic activity of bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex [J].

Katoh, A ;

Tsukahara, T ;

Saito, R ;

Ghosh, KK ;

Yoshikawa, Y ;

Kojima, Y ;

Tamura, A ;

Sakurai, H .

CHEMISTRY LETTERS, 2002, (01) :114-115

[4] Pharmacokinetic study of allixin, a phytoalexin produced by garlic [J].

Kodera, Y ;

Ichikawa, M ;

Yoshida, J ;

Kashimoto, N ;

Uda, N ;

Sumioka, I ;

Ide, N ;

Ono, K .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (03) :354-363

[5]

NAKAI M, 1995, BIOL PHARM BULL, V18, P719

[6] New antidiabetic vanadyl-pyridone complexes: effect of equivalent transformation of coordinating atom in the ligand [J].

Sakurai, H ;

Tamura, A ;

Fugono, J ;

Yasui, H ;

Kiss, T .

COORDINATION CHEMISTRY REVIEWS, 2003, 245 (1-2) :31-37

[7] Antidiabetic vanadium(IV) and zinc(II) complexes [J].

Sakurai, H ;

Kojima, Y ;

Yoshikawa, Y ;

Kawabe, K ;

Yasui, H .

COORDINATION CHEMISTRY REVIEWS, 2002, 226 (1-2) :187-198

[8] Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice [J].

Suto, J ;

Matsuura, S ;

Imamura, K ;

Yamanaka, H ;

Sekikawa, K .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 139 (06) :654-661

[9]

Wild S., 2003, GLOBAL BURDEN DIS

[10] New insulin-mimetic zinc (II) complexes;: Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O4) coordination mode [J].

Yoshikawa, Y ;

Ueda, E ;

Kawabe, K ;

Miyake, H ;

Sakurai, H ;

Kojima, Y .

CHEMISTRY LETTERS, 2000, (08) :874-875