Asymmetric synthesis of the quinolizidine alkaloid (-)-epimyrtine with intramolecular Mannich Cyclization and n-sulfinyl δ-amino β-ketoesters

被引：79

作者：

Davis, FA ^{[1
]}

Mang, Y ^{[1
]}

Anilkumar, G ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 21期

关键词：

D O I：

10.1021/jo030208d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, six-step, enantioselective synthesis of (-)-epimyrtine employing the N-sulfinyl delta-amino beta-ketoester chiral building block is described.

引用

页码：8061 / 8064

页数：4

共 15 条

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[7] Intramolecular Mannich reaction in the asymmetric synthesis of polysubstituted piperidines: Concise synthesis of the dendrobate alkaloid (+)-241D and its C-4 epimer
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[8] δ-amino β-keto esters, a designed polyfunctionalized chiral building block for alkaloid synthesis.: Asymmetric synthesis of (R)-(+)-2-phenylpiperidine and (-)-SS20846A
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