Sulfur-specific detection of impurities in cimetidine drug substance using liquid chromatography coupled to high resolution inductively coupled plasma mass spectrometry and electrospray mass spectrometry

被引：38

作者：

Evans, EH

Wolff, JC

Eckers, C

机构：

[1] Univ Plymouth, Dept Environm Sci, Plymouth Environm Res Ctr, Plymouth PL4 8AA, Devon, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

ANALYTICAL CHEMISTRY | 2001年 / 73卷 / 19期

关键词：

D O I：

10.1021/ac0103017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of liquid chromatography coupled to sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) for the specific detection of sulfur-containing compounds is described. In the sulfur-containing drug substance cimetidine, structurally related impurities well below the 0.1 % mass fraction. level relative to the main drug substance could easily be detected. The structure of most of the impurities was confirmed by electrospray mass spectrometry (ESI-MS), and thus, the complementarity of the two techniques for drug analysis is shown. The limit of detection by SF-ICP-MS for cimetidine in solution was similar to4-20 ng.g(-1), but it was blank-limited.

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收藏

页码：4722 / 4728

页数：7

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