Synthesis of a C3-symmetric (1→6)-N-acetyl-β-D-glucosamine octadecasaccharide using click chemistry

被引：41

作者：

Chen, Q ^{[1
]}

Yang, F ^{[1
]}

Du, YG ^{[1
]}

机构：

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2005年 / 340卷 / 16期

基金：

中国国家自然科学基金;

关键词：

glycosylation; click chemistry; glucosamine; antitumor activity; thioglycosides;

D O I：

10.1016/j.carres.2005.08.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A C-3-symmetric (1-->6)-N-acetyl-beta-D-glucosamine octadecasaccharide was convergently synthesized on the basis of a copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of azide and alkyne. The target octadecasaccharide showed good antitumor activity against H22 in the preliminary mice tests. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2476 / 2482

页数：7

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