Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons

被引：46

作者：

Gerevich, Z ^{[1
]}

Müller, C ^{[1
]}

Illes, P ^{[1
]}

机构：

[1] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, D-04107 Leipzig, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 521卷 / 1-3期

关键词：

pain; sensory neuron; electrophysiology;

D O I：

10.1016/j.ejphar.2005.08.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whole-cell patch-clamp recordings from cultured rat dorsal root ganglion neurons demonstrated that the P2Y(1) receptor agonists adenosine 5'-0-2-thiodiphosphate (ADP-beta-S) and 2-methylthio adenosine 5'-diphosphate (2-MeSADP) inhibit the alpha,beta-methylene adenosine 5'-triphosphate (alpha,beta-meATP)-induced P2X(3) receptor-currents. This effect could be antagonized by the wide-spectrum G protein blocker GDP- beta-S and the P2Y(1) receptor antagonist MRS 2179. The P2Y(12,13) receptor antagonist AR-C6993MX and pertussis toxin, a blocker of G alpha(i/o), did not interact with the effect of ADP-beta-S. Hence, the results indicate that ADP-sensitive P2Y(1) receptors of rat dorsal root ganglion neurons inhibit ionotropic P2X(3) receptors via G protein-activation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：34 / 38

页数：5

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