Age-dependent changes in thymic macrophages and dendritic cells

被引：35

作者：

Varas, A

Sacedón, R

Hernandez-López, C

Jiménez, E

García-Ceca, J

Arias-Díaz, J

Zapata, AG

Vicente, A

机构：

[1] Univ Complutense, Fac Med, Dept Cell Biol, E-28040 Madrid, Spain

[2] Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain

[3] Univ Complutense, Fac Med, Dept Surg, E-28040 Madrid, Spain

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 2003年 / 62卷 / 06期

关键词：

thymic involution; phagocytosis; allostimulation; costimulatory molecules; chemokine receptors; SURFACE MARKER ANALYSIS; BONE-MARROW-CELLS; T-CELL; PERITONEAL-MACROPHAGES; PERIPHERAL-BLOOD; MOUSE THYMUS; MURINE MACROPHAGES; EPITHELIAL-CELLS; NATURAL-KILLER; INTRATHYMIC T;

D O I：

10.1002/jemt.10411

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Aging is characterized by the decline and deregulation of several physiological systems, especially the immune system. The involution of the thymus gland has been identified as one of the key events that precedes the age-related decline in immune function. Whereas the decrease in thymocyte numbers and in the thymic output during thymus atrophy has been analyzed by various authors, very little information is available about the age-associated modifications in thymic macrophages and dendritic cells. Here we present evidence that these thymic stromal cell components are only slightly affected by age. (C) 2003 Wiley-Liss, Inc.

引用

页码：501 / 507

页数：7

共 117 条

[11] Thymic atrophy in the mouse is a soluble problem of the thymic environment [J].