The immunomodulatory properties of mesenchymal stem cells

被引：133

作者：

Marigo, Ilaria ^{[1
]}

Dazzi, Francesco ^{[1
]}

机构：

[1] Hammersmith Hosp, Div Expt Med, Dept Med, London W12 ONN, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2011年 / 33卷 / 06期

基金：

英国医学研究理事会;

关键词：

Mesenchymal stem cells; Stromal cells; Bone marrow; Tissue repair; Tumour; Fibrosis; MARROW STROMAL CELLS; BONE-MARROW; PROGENITOR CELLS; IN-VITRO; T-CELLS; LYMPHOCYTE-PROLIFERATION; INTERFERON-BETA; GENE-EXPRESSION; MYELOMA CELLS; B-CELLS;

D O I：

10.1007/s00281-011-0267-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research on mesenchymal stem cells (MSC) has evolved rapidly during the last decade prompted by their potential use for tissue repair and immunotherapy. Not only can MSC differentiate into cells of the mesodermal lineage, but they also exhibit immunomodulatory functions depending on their interaction with cells of both innate and adaptive immune systems. Most aspects of MSC biology remain to be elucidated. It is emerging even more clearly that these cells are not always a panacea. Only the knowledge of their physiological role and their interactions with other cells will allow us to use them as a therapeutic tool.

引用

页码：593 / 602

页数：10

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