The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine

被引：67

作者：

Mills, EM

Rusyniak, DE

Sprague, JE

机构：

[1] Virginia Polytech Inst & State Univ, Edward Via Virginia Coll Osteopath Med, Blacksburg, VA 24060 USA

[2] NHLBI, NIH, Bethesda, MD 20892 USA

[3] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA

[4] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24060 USA

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2004年 / 82卷 / 12期

关键词：

3,4-methylenedioxymethamphetamine; rhabdomyolysis; hyperthermia; uncoupling proteins UCP-3;

D O I：

10.1007/s00109-004-0591-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Body temperature regulation involves a homeostatic balance between heat production and dissipation. Sympathetic agents such as 3,4-methylenedioxymethamphetarnine (MDMA, ecstasy) can disrupt this balance and as a result produce an often life-threatening hyperthermia. The hyperthermia induced by MDMA appears to result from the activation of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-thyroid/adrenal axis. Norepinephrine release mediated by MDMA creates a double-edged sword of heat generation through activation of uncoupling protein (UCP3) along with alpha(1)- and beta(3)-adrenoreceptors and loss of heat dissipation through SNS-mediated vasoconstriction. This review examines cellular mechanisms involved in MDMA-induced thermogenesis from UCP activation to vasoconstriction and how these mechanisms are related to other thermogenic conditions and potential treatment modalities.

引用

页码：787 / 799

页数：13

共 158 条

[1] Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene [J].