Plasmonic Nanoparticle Dimers for Optical Sensing of DNA in Complex Media

被引：168

作者：

Chen, Jennifer I. L. ^{[1
]}

Chen, Yeechi ^{[1
]}

Ginger, David S. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 28期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ASYMMETRIC FUNCTIONALIZATION; GOLD; PROTEIN; ADSORPTION; RESISTANCE; SENSORS;

D O I：

10.1021/ja103240g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy. The magnitude and opposite direction of this shift enabled us to spectroscopically distinguish the target from nonspecific binding and to detect the target in complex media like serum.

引用

页码：9600 / 9601

页数：2

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