Transcriptional control of COX-2 via C/EBPβ

被引：62

作者：

Wu, KK

Liou, JY

Cieslik, K

机构：

[1] Univ Texas, Hlth Sci Ctr, Vasc Biol Res Ctr, Inst Mol Med, Houston, TX 77030 USA

[2] Univ Texas, Hlth Sci Ctr, Div Hematol, Houston, TX 77030 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2005年 / 25卷 / 04期

关键词：

aspirin; C/EBP; COX-2; inflammation; NF-kappa B;

D O I：

10.1161/01.ATV.0000157899.35660.61

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclooxygenase-2 (COX-2) is a highly inducible enzyme exerting diverse actions on cell functions, including proliferation, migration, and DNA damage. Enhanced COX-2 expression may be protective, but excessive expression may be harmful, causing inflammation, atheromatous plaque instability, and intimal hyperplasia. COX-2 transcriptional activation by proinflammatory mediators has been extensively characterized. In this review, the role of C/EBP in regulating COX- 2 transcription is highlighted. Recent advances in control of COX- 2 transcription by aspirin and salicylate and by a cell cycle - dependent endogenous mechanism are described. The recent progress sheds light on the pathophysiological mechanisms of COX- 2 and new transcription-based strategy for controlling COX- 2 overexpression and COX- 2 - mediated cardiovascular diseases.

引用

收藏

页码：679 / 685

页数：7

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