Silver-Catalyzed Late-Stage Fluorination

被引:277
作者
Tang, Pingping [1 ]
Furuya, Takeru [1 ]
Ritter, Tobias [1 ]
机构
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
关键词
REDUCTIVE ELIMINATION; FUNCTIONALIZED ARYL; BOND FORMATION; REACTIVITY; CHEMISTRY;
D O I
10.1021/ja105834t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Carbon-fluorine bond formation by transition metal catalysis is difficult, and only a few methods for the synthesis of aryl fluorides have been developed. All reported transition-metal-catalyzed fluorination reactions for the synthesis of functionalized arenes are based on palladium. Here we present silver catalysis for carbon-fluorine bond formation. Our report is the first example of the use of the transition metal silver to form carbon-heteroatom bonds by cross-coupling catalysis. The functional group tolerance and substrate scope presented here have not been demonstrated for any other fluorination reaction to date.
引用
收藏
页码:12150 / 12154
页数:5
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