Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats

被引：95

作者：

Little, DG ^{[1
]}

Peat, RA

McEvoy, A

Williams, PR

Smith, EJ

Baldock, PA

机构：

[1] Childrens Hosp, Orthopaed Res Unit, Westmead, NSW, Australia

[2] Univ Sydney, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia

[3] St Vincents Hosp, Garvan Inst Med Res, Bone & Mineral Program, Darlinghurst, NSW 2010, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

bisphosphonates; rodent; bone densitometry; modeling and remodeling; bone histomorphometry;

D O I：

10.1359/jbmr.2003.18.11.2016

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Osteonecrosis (ON) of the femoral head in childhood can lead to loss of femoral head architecture and subsequent deformity. When femoral head ON was surgically induced in 24 rats, zoledronic acid treatment and prophylaxis improved sphericity and maintenance of architecture at 6 weeks. This preliminary experiment supports the use of bisphosphonates in childhood ON.

引用

页码：2016 / 2022

页数：7

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