Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy

被引：83

作者：

Shachaf, CM

Felsher, DW

机构：

[1] Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Oncol, Div Oncol, Stanford, CA 94305 USA

来源：

CANCER RESEARCH | 2005年 / 65卷 / 11期

关键词：

D O I：

10.1158/0008-5472.CAN-05-1172

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Upon MYC inactivation, tumors undergo proliferative arrest, cellular differentiation, apoptosis and in some cases, permanently revoke tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, their neoplastic properties are restorable by MYC reactivation. Thus, whereas oncogene inactivation can push cancer to the brink of normalcy, some cells retain the latent capacity to turn cancerous again, arguing that they may exist in a state of tumor dormancy.

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收藏

页码：4471 / 4474

页数：4

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