Efficient one-pot synthesis of 2-oxo-1,9a-dihydro-2H-pyrido-[1,2-a]pyrimidine derivatives

被引：33

作者：

Adib, M ^{[1
]}

Yavari, H ^{[1
]}

Mollahosseini, M ^{[1
]}

机构：

[1] Univ Tehran, Fac Sci, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 08期

关键词：

pyridines; acetylenic esters; isocyanates; 2-oxo-1,9a-dihydro-2H-pyrido[1,2-a]pyrimidine; derivatives;

D O I：

10.1016/j.tetlet.2003.12.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridines react smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,9a-dihydro-2H-pyrido[1,2-a]pyrimidine 3,4-dicarboxylates in excellent yields. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1803 / 1805

页数：3

共 17 条

[1] ADDITION REACTIONS OF HETEROCYCLIC COMPOUNDS .21. NUCLEAR MAGNETIC RESONANCE SPECTRA OF SOME QUINOLIZINES AND THEIR SALTS AND NEW ADDUCTS FROM ALKYLPYRIDINES
ACHESON, RM
FEINBERG, RS
GAGAN, JMF
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1965, (FEB): : 948 - &
[2] ADDITION REACTIONS OF HETEROCYCLIC COMPOUNDS .33. NEW ADDUCTS FROM SOME PYRIDINES AND DIMETHYL ACETYLENEDICARBOXYLATE
ACHESON, RM
FOXTON, MW
HANDS, AR
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1968, (04): : 387 - &
[3] [Anonymous], ADV HETEROCYCL CHEM
[4] [Anonymous], COMPR HETEROCYCL CHE
[5] BOGDANOV VS, 1995, MENDELEEV COMMUN, P106
[6] Discovering risperidone: the LSD model of psychopathology
Colpaert, FC
[J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (04) : 315 - 320
[7] Dehydroacetic acid precursor of a novel pyridopyrimidine, thiazolo-pyrimidine and pyridone
Djerrari, B
Essassi, EM
Fifani, J
Garrigues, B
[J]. COMPTES RENDUS CHIMIE, 2002, 5 (03) : 177 - 183
[8] Friebolin H, 1998, BASIC ONE 2 DIMENSIO
[9] Cyclisation of 3-alkenylpyrido[1,2-a]pyrimidines to furo[2,3-d]pyrido[1,2-a]pyrimidines
Güllü, M
Uzun, S
Yulçun, S
[J]. TETRAHEDRON LETTERS, 2003, 44 (09) : 1939 - 1941
[10] LASZLO P, 1995, ORGANIC REACTIONS SI

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