Evidence for the contribution of LTR retrotransposons to C-elegans gene evolution

被引：49

作者：

Ganko, EW ^{[1
]}

Bhattachajee, V

Schliekelman, P

McDonald, JF

机构：

[1] Univ Georgia, Dept Genet, Athens, GA 30602 USA

[2] Univ Georgia, Dept Stat, Athens, GA 30602 USA

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2003年 / 20卷 / 11期

关键词：

C; elegans; LTR retrotransposon; gene evolution; genome evolution;

D O I：

10.1093/molbev/msg200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LTR retrotransposons may be important contributors to host gene evolution because they contain regulatory and coding signals. In an effort to assess the possible contribution of LTR retrotransposons to C. elegans gene evolution, we searched upstream and downstream of LTR retrotransposon sequences for the presence of predicted genes. Sixty-three percent of LTR retrotransposon sequences (79/124) are located within 1 kb of a gene or within gene boundaries. Most gene-retrotransposon associations were located along the chromosome arms. Our results are consistent with the hypothesis that LTR retrotransposons have contributed to the structural and/or regulatory evolution of genes in C. elegans.

引用

页码：1925 / 1931

页数：7

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