Dynamics of Salivary Gland Morphogenesis

被引：59

作者：

Harunaga, J. ^{[1
]}

Hsu, J. C. ^{[1
]}

Yamada, K. M. ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Lab Cell & Dev Biol, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2011年 / 90卷 / 09期

关键词：

developmental biology; cell-matrix interactions; microscopy; gene expression; cell signaling; tissue engineering; MOUSE SUBMANDIBULAR-GLAND; ADENOVIRAL-MEDIATED TRANSFER; INCREASED FLUID SECRETION; BRANCHING MORPHOGENESIS; DEVELOPING KIDNEY; AQUAPORIN-1; CDNA; SYSTEMS-ANALYSIS; GENE-EXPRESSION; MYOSIN-II; CELL;

D O I：

10.1177/0022034511405330

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Salivary glands form during embryonic development by a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The architecture of these glands is generated by branching morphogenesis, revealed by recent research to involve unexpectedly dynamic cell motility and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Here we review these recent advances and their potential application to salivary gland tissue engineering.

引用

页码：1070 / 1077

页数：8

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