Synthesis, acidity and F-19 NMR characteristics of imidazoles bearing 1-fluorinated substituents with potential application as probes for intracellular pH determination.

被引：17

作者：

Harper, JL

Smith, RAJ

Bedford, JJ

Leader, JP

机构：

[1] UNIV OTAGO, DEPT CHEM, DUNEDIN, NEW ZEALAND

[2] UNIV OTAGO, SCH MED SCI, DEPT PHYSIOL, DUNEDIN, NEW ZEALAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(97)00487-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1-substituted imidazoles containing fluorine have been prepared. These compounds were identified as potentially useful probes for intracellular pH determination based on F-19 NMR. Key parameters including pK(a), F-19 NMR chemical shift sensitivity, water solubility and low toxicity were identified and included in the target molecule selection process. The pK(a) and F-19 NMR parameters of the molecules are reported and vends analysed. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：8211 / 8224

页数：14

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