Regulation of gene expression by HTLV-I tax protein

被引：97

作者：

Bex, F ^{[1
]}

Gaynor, RB

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Div Hematol Oncol, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Microbiol, Div Hematol Oncol, Dallas, TX 75235 USA

[3] Univ Brussels, Dept Mol Biol, Brussels, Belgium

来源：

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY | 1998年 / 16卷 / 01期

关键词：

D O I：

10.1006/meth.1998.0646

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A protein encoded by HTLV-I, Tax, activates viral gene expression and Is essential for transforming T-lymphocytes. Tax activates HTLV-I gene expression via interactions with the ATF/CREB proteins and the coactivators CBP/p300 which assemble as a multiprotein complex on regulatory elements known as 21-bp repeats in the HTLV-I LTR. Tax can also activate expression from cellular genes including the interleukin-2 (IL-2) and the IL-2 receptor genes via increases in nuclear levels of NF-kappa B. Tax modulation of gene expression via the ATF/CREB and NF-kappa B pathways is linked to its transforming properties. This review discusses the mechanisms by which Tax regulates viral and cellular gene expression. (C) 1998 Academic Press.

引用

页码：83 / +

页数：14

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