Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves

被引：46

作者：

Carretero, M. E. ^{[1
]}

Lopez-Perez, J. L. ^{[3
]}

Abad, M. J. ^{[1
]}

Bermejo, P. ^{[1
]}

Tillet, S. ^{[5
]}

Israel, A. ^{[4
]}

Noguera-P, B. ^{[2
]}

机构：

[1] Univ Complutense Madrid, Sch Pharm, Dept Pharmacol, E-28040 Madrid, Spain

[2] Cent Univ Venezuela, Sch Pharm, Dept Nat Prod, Caracas 40109, DC, Venezuela

[3] Univ Salamanca, Sch Pharm, Dept Pharmaceut Chem, Salamanca 37007, Spain

[4] Cent Univ Venezuela, Lab Neuropeptidos, Sch Pharm, Caracas 40109, DC, Venezuela

[5] Cent Univ Venezuela, Herbario Victor Manuel Ovalles MYF, Sch Pharm, Caracas 40109, DC, Venezuela

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2008年 / 116卷 / 01期

关键词：

Bursera simaruba (L.) Sarg. leaf; anti-inflammatory; 3-methylene-7,11,15-trimethylhexadec-1-ene (neophytadiene); ergost-5-en-3; beta-ol; 24S-stigmast-5,22E-dien-3 beta-ol; 24S-stigmast-5-en-3; alpha-amyrin;

D O I：

10.1016/j.jep.2007.10.034

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bursera simaruba (L.) Sarg. leaves hexane extracts display anti-inflammatory activity on the adjuvant-carrageenan-induced inflammation in rats. In order to isolate and identify the active compounds of the hexane extract, we performed a preliminary phytochemical study and a bioassay-directed fractionation using the carrageenan-induced paw oedema test in mice. From the nine fractions (A-I) obtained, of an initial chromatographic separation, fractions A and E (doses equivalents to 1.50 g dry plant/kg body weight) showed the strongest anti-inflammatory activity comparable to that of the reference drug phenylbutazone (80 mg/kg). The isolation and characterization of 3-methylene-7,11,15-trimethylhexadec-1-ene (neophytadiene) (1), ergost-5-en-3 beta-ol (2), 24S-stigmast-5,22E-dien-3 beta-ol (3), 24S-stigmast-5-en-3 beta-ol (4) and alpha-amyrin (5), from these fractions is reported. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：11 / 15

页数：5

共 17 条

[1] Antiinflammatory activity of some medicinal plant extracts from Venezuela [J].

Abad, MJ ;

Bermejo, P ;

Carretero, E ;

MartinezAcitores, C ;

Noguera, B ;

Villar, A .

JOURNAL OF ETHNOPHARMACOLOGY, 1996, 55 (01) :63-68

[2] Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects [J].

Akihisa, T ;

Yasukawa, K ;

Oinuma, H ;

Kasahara, Y ;

Yamanouchi, S ;

Takido, M ;

Kumaki, K ;

Tamura, T .

PHYTOCHEMISTRY, 1996, 43 (06) :1255-1260

[3]

ALCARAZ M J, 1988, Fitoterapia, V59, P25

[4]

DELASCIO F, 1985, ALGUNAS PLANTAS USAD, P22

[5] ANTI-INFLAMMATORY AND ANTI-PYRETIC ACTIVITIES OF BETA-SITOSTEROL [J].

GUPTA, MB ;

NATH, R ;

SRIVASTAVA, N ;

SHANKER, K ;

KISHOR, K ;

BHARGAVA, KP .

PLANTA MEDICA, 1980, 39 (02) :157-163

[6] ANTI-INFLAMMATORY ACTIVITY OF NATURAL PRODUCTS .I. TRITERPENOIDS [J].

GUPTA, MB ;

BHALLA, TN ;

GUPTA, GP ;

MITRA, CR ;

BHARGAVA, KP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1969, 6 (01) :67-+

[7]

Iarenko D. B, 1998, LIK SPARAVA, V7, P48

[8] A PENTACYCLIC TRITERPENE DIACID FROM MYRIANTHUS-ARBOREUS [J].

NGOUNOU, FN ;

LONTSI, D ;

SONDENGAM, BL .

PHYTOCHEMISTRY, 1988, 27 (07) :2287-2289

[9]

RECIO MD, 1995, PLANTA MED, V61, P182, DOI 10.1055/s-2006-958045

[10] ANTIINFLAMMATORY ACTIVITY OF OLEANOLIC ACID IN RATS AND MICE [J].

SINGH, GB ;

SINGH, S ;

BANI, S ;

GUPTA, BD ;

BANERJEE, SK .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1992, 44 (05) :456-458

← 1 2 →