Functional relevance of human ADH polymorphism

被引：49

作者：

Eriksson, CJP

Fukunaga, T

Sarkola, T

Chen, WJ

Chen, CC

Ju, JM

Cheng, ATA

Yamamoto, H

Kohlenberg-Müller, K

Kimura, M

Murayama, M

Matsushita, S

Kashima, H

Higuchi, S

Carr, L

Viljoen, D

Brooke, L

Stewart, T

Foroud, T

Su, J

Li, TK

Whitfield, JB

机构：

[1] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, Helsinki 00101, Finland

[2] Mie Univ, Sch Med, Dept Forens Med & Sci, Tsu, Mie 514, Japan

[3] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei 10764, Taiwan

[4] Taipei City Psychiat Ctr, Dept Adult Psychiat, Taipei, Taiwan

[5] Acad Sinica, Inst Biomed Sci, Div Epidemiol & Publ Hlth, Taipei 115, Taiwan

[6] Univ Appl Sci Fulda, Fulda, Germany

[7] Kurihama Natl Hosp, Div Clin Res, Natl Inst Alcoholism, Yokosuka, Kanagawa, Japan

[8] Akagi Kougen Hosp, Gunma, Japan

[9] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[10] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46204 USA

[11] Fdn Alcohol Related Res, Cape Town, South Africa

[12] Royal Prince Alfred Hosp, Dept Clin Biochem, Camperdown, NSW 2050, Australia

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2001年 / 25卷 / 05期

关键词：

ADH2; ADH3; polymorphism; alcohol drinking; flushing; birth defects;

D O I：

10.1111/j.1530-0277.2001.tb02391.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were C. J. Peter Eriksson and Tatsushige Fukunaga. The presentations were (1) 4-Methylpyrazole as a tool in the investigation of the role of ADH in the actions of alcohol in humans, by Taisto Sarkola and C. J. Peter Eriksson; (2)ADH2 polymorphism and flushing in Asian populations, by Wei J. Chen, C. C. Chen, J. M. Ju, and Andrew T. A. Cheng; (3) Role of ADH3 genotypes in the acute effects of alcohol in a Finnish population, by Hidetaka Yamamoto, Kathrin Kohlenberg-Muller, and C. J. Peter Eriksson; (4) Clinical characteristics and disease course of alcoholics with different ADH2 genotypes, by Mitsuru Kimura, Masanobu Murayama, Sachio Matsushita, Haruo Kashima, and Susumu Higuchi; (5) ADH2 polymorphism, alcohol drinking, and birth defects, by Lucinda Carr, D. Viljoen, L. Brooke, T. Stewart, T. Foroud, J. Su, and Ting-Kai Li; and (6) ADH genotypes and alcohol use in Europeans, by John B. Whitfield.

引用

页码：157S / 163S

页数：7

共 41 条

[1] Genetic polymorphism of alcohol dehydrogenase in Europeans:: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1 [J].