Repair of DNA covalently linked to protein

被引：76

作者：

Connelly, JC ^{[1
]}

Leach, DRF ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

MOLECULAR CELL | 2004年 / 13卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1097-2765(04)00056-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A potentially lethal form of DNA/RNA modification, a cleavage complex, occurs when a nucleic acid-processing enzyme that acts via a transient covalent intermediate becomes trapped at its site of action. A number of overlapping pathways act to repair these lesions and many of the enzymes involved are those that catalyze recombinational-repair processes. A protein, Tdp1, has been identified that reverses cleavage-complex formation by specifically hydrolyzing a tyrosyl-DNA phosphodiester bond. The study of these pathways is both interesting and pertinent as they modulate the effectiveness of many antitumor/antibacterial drugs that act by stabilizing cleavage-complexes in vivo.

引用

页码：307 / 316

页数：10

共 53 条

[11] Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures
Davies, DR
Interthal, H
Champoux, JJ
Hol, WGJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 324 (05) : 917 - 932
[12] The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1
Davies, DR
Interthal, H
Champoux, JJ
Hol, WGJ
[J]. STRUCTURE, 2002, 10 (02) : 237 - 248
[13] Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase
Debéthune, L
Kohlhagen, G
Grandas, A
Pommier, Y
[J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (05) : 1198 - 1204
[14] Transcription-dependent degradation of topoisomerase I-DNA covalent complexes
Desai, SD
Zhang, H
Rodriguez-Bauman, A
Yang, JM
Wu, XH
Gounder, MK
Rubin, EH
Liu, LF
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (07) : 2341 - 2350
[15] EISEN JA, 1999, MUTAT RES, V2, P795
[16] ENG WK, 1988, MOL PHARMACOL, V34, P755
[17] Structure of a trapped endonuclease III-DNA covalent intermediate
Fromme, JC
Verdine, GL
[J]. EMBO JOURNAL, 2003, 22 (13) : 3461 - 3471
[18] Purification of a mammalian homologue of Escherichia coli endonuclease III: Identification of a bovine pyrimidine hydrate thymine glycol DNA-glycosylase AP lyase by irreversible cross linking to a thymine glycol-containing oligodeoxynucleotide
Hilbert, TP
Boorstein, RJ
Kung, HC
Bolton, PH
Xing, SX
Cunningham, RP
Teebor, GW
[J]. BIOCHEMISTRY, 1996, 35 (08) : 2505 - 2511
[19] Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisome rase complexes
Hong, G
Kreuzer, KN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) : 5046 - 5051
[20] SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin
Horie, K
Tomida, A
Sugimoto, Y
Yasugi, T
Yoshikawa, H
Taketani, Y
Tsuruo, T
[J]. ONCOGENE, 2002, 21 (52) : 7913 - 7922

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