Inhibition studies on salicylate synthase

被引：26

作者：

Payne, RJ

Kerbarh, O

Miguel, RN

Abell, AD

Abell, C

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[3] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b503800f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Analogues of chorismate and isochorismate were designed and tested as potential inhibitors in the first inhibition study against a salicylate synthase.

引用

页码：1825 / 1827

页数：3

共 21 条

[1] The Protein Data Bank [J].

Berman, HM ;

Westbrook, J ;

Feng, Z ;

Gilliland, G ;

Bhat, TN ;

Weissig, H ;

Shindyalov, IN ;

Bourne, PE .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242

[2] Bacterial solutions to the iron supply problem [J].

Braun, V ;

Killmann, H .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (03) :104-109

[3] Genetics and assembly line enzymology of siderophore biosynthesis in bacteria [J].

Crosa, JH ;

Walsh, CT .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (02) :223-+

[4] Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa [J].

Gaille, C ;

Reimmann, C ;

Haas, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :16893-16898

[5] Salicylate biosynthesis in Pseudomonas aeruginosa -: Purification and characterization of PchB, a novel bifunctional enzyme displaying isochorismate pyruvate-lyase and chorismate mutase activities [J].

Gaille, C ;

Kast, P ;

Haas, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21768-21775

[6]

KERBARH O, UNPUB

[7] The crystal structure of anthranilate synthase from Sulfolobus solfataricus:: Functional implications [J].

Knöchel, T ;

Ivens, A ;

Hester, G ;

Gonzalez, A ;

Bauerle, R ;

Wilmanns, M ;

Kirschner, K ;

Jansonius, JN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9479-9484

[8] CHORISMATE-UTILIZING ENZYMES ISOCHORISMATE SYNTHASE, ANTHRANILATE SYNTHASE, AND P-AMINOBENZOATE SYNTHASE - MECHANISTIC INSIGHT THROUGH INHIBITOR DESIGN [J].

KOZLOWSKI, MC ;

TOM, NJ ;

SETO, CT ;

SEFLER, AM ;

BARTLETT, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (08) :2128-2140

[9] PROCHECK - A PROGRAM TO CHECK THE STEREOCHEMICAL QUALITY OF PROTEIN STRUCTURES [J].

LASKOWSKI, RA ;

MACARTHUR, MW ;

MOSS, DS ;

THORNTON, JM .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1993, 26 :283-291

[10] ASSESSMENT OF PROTEIN MODELS WITH 3-DIMENSIONAL PROFILES [J].

LUTHY, R ;

BOWIE, JU ;

EISENBERG, D .

NATURE, 1992, 356 (6364) :83-85

← 1 2 3 →